Presenilin 2 anticorps (N-Term)

N° du produit ABIN3032302

Cet anticorps Lapin Polyclonal détecte spécifiquement Presenilin 2 dans WB, IHC (p) et IHC (fro). Il présente une réactivité envers Humain, Rat et Souris.

Aperçu rapide pour Presenilin 2 anticorps (N-Term) (ABIN3032302)

Antigène: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Presenilin 2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-Presenilin 2 anticorps

Épitope: N-Term

Purification: Antigen affinity

Immunogène: An amino acid sequence from the N-terminus of human Presenilin 2(EDGENTAQWRSQE) was used as the immunogen for this Presenilin 2 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the Presenilin 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,IHC (Frozen): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the Presenilin 2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur Presenilin 2

Antigène: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Autre désignation: Presenilin 2

Sujet: Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene. Kovacs et al.(1996) demonstrated that the expression patterns of PS1 and PS2 in the brain are extremely similar to each other and that messages for both are primarily detectable in neuronal populations. Immunochemical analyses indicated that PS1 and PS2 are similar in size and localize to similar intracellular compartments(endoplasmic reticulum and Golgi complex). Li et al.(1997) demonstrated that wildtype PS1 and PS2 are localized to the nuclear membrane, its associated interphase kinetochores, and the centrosomes.In melanocytic cells PSEN2 gene expression may be regulated by MITF.

UniProt: P49810

Pathways: Signalisation Notch, EGFR Signaling Pathway, Neurotrophin Signaling Pathway